1971 MD, University Medical School of Debrecen, Hungary
1971-1976 FRCP (H, EU conform) - Board certified in Neurology, University Medical School of Debrecen, Hungary
1976-1982 FRCP (H, EU conform) Board certified in Psychiatry and Psychotherapy, National Institute of Neurology and Psychiatry, Budapest, Hungary
1982-2005 PD (Dr. habil. or DSc) and MER, Neuropathology, University Institute of Pathology, CHUV, University of Lausanne, Switzerland
2005 PhD, University Medical School of Debrecen, (DOTE), Director of thesis PL McGeer, University of British Columbia, Vancouver, Canada
2010 FRCP (FMH, EU conform) Board certified in Neuropathology, Fédération des Médecins suisses, Switzerland
ACADEMIC AND CLINICAL APPOINTMENTS
1967-1971 Resident, Neurobiology research, Institute of Physiology, DOTE, Debrecen, Hungary
1971-1976 Resident, Instructor, neurologist, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, Debrecen, Hungary
1977-1982 Instructor, Staff member, Psychiatry, National Institute of Neurology and Psychiatry, OIEI, Budapest, Hungary
1982-2005 Neuropathology, Médecin associé, Staff member, University Medical School of Lausanne, Switzerland
1995- Head of “Neurodegeneration” research group. University Institute of Pathology
1995 PD (Dr. habil. or DSc), MER (assistant professor) CHUV, UNIL, Lausanne, Switzerland
2001-2004 Molecular biology, Center for NeuroVirology, Temple University, Philadelphia, PA, USA
2004 – 2006 Neurological research, Kinsmen Laboratory of Neurological Research, The British Columbia University, Vancouver, BC, Canada
2010 Director of International Alzheimer Research Center of Prevention Alzheimer International Foundation, Switzerland
AWARDS AND HONORS
1971 MD degree (cum laude) University Medical School of Debrecen, Hungary: Second national and first university prize of distinction for doctoral thesis.
1975 Specialty board Exam and Certificate in Neurology with distinction 5/5
1976 Best young researcher award, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, University of Debrecen, Hungary
1980 Specialty board Exam and Certificate in Psychiatry, FRCP with distinction 5/5
1995 PD (DSc or Dr habil.) and MER – (equivalent assistant professor), University Institute of Pathology, Lausanne, Switzerland
2005 PhD degree, (summa cum laude), University Medical School of Debrecen, Hungary
Member of various scientific organizations and associations related to neuroscience.
Member of Director Physicians of Swiss Hospitals
2005- 2012 On the Board of Directors and from 2009-2012 scientific advisor of the Canadian Lyme Association, 2007- On the Scientific Advisory Board of German Borreliosis Society (Borreliose-Gesellschaft, Germany), On the Board of scientific advisory panel of Lyme Research Alliance in partnership with Columbia University Medical Center in New York City.
Number of publications (articles, book chapters and published abstracts: 238)
Published articles and book chapters: 111 (104 per reviewed)
Mean impact factor: 5.02
1. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572.
3. Miklossy J, Van der Loos H. The long distance effects of brain lesions: A study of myelinated pathways in the human brain using polarizing and fluorescence microscopy. J Neuropathol Exp Neurol 1991;50:1-15.
4. Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M. Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol. 1999;58:803-814.
5. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 2000;24:291-295. Press release.
6. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537. Press release.
7. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer’s Dissease 2004, 6 (6): 1-11.
8. Helbecque N, Abderrhamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger J, Cottel D, Amouyel P, Froguel P, Waeber G. Islet-Brain 1/ C-Jun N-terminal Kinase Interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer’s disease. Molecular Psychiatry 2003;8:413-22.
9. Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fischer C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging. 2003;24:655-662.
10. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. Proc Natl Acad Sci U S A. 2006 ;103:1953-8. Press release.
11. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins RN, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 2006;27:228-236.
13. Miklossy J. Biology and neuropathology of dementia in syphilis and Lyme disease. In Handbook of Clinical Neurology, Vol 89 (3rd series) C Duyckaerts, I Litvan, Editors, 3008, Elsevier B.V. Chapter of Handbook of Neurology Handbook of Clinical Neurology, 2008; 89: 825-844.
Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease – role of spirochetes. J. Alzheimer’s Dis. 2008;13: 381.391. http://www.j-alz.com/issues/13/vol13-4.html
15. Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyper-phosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging. 2010, 31:1503-1511.
16. Miklossy J, Kasas S, Zurn A, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J. Neuroinflammation. 2008, 5:40
17. Miklossy J, Martins RN, Darbinian N, Khalili K, McGeer PL. Type 2 diabetes: Local inflammation and direct effect of bacterial toxic products. Open Pathol J, 2008, 2: 86-95
18. Miklossy J. Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J Neuroinflammation. 2011 Aug 4;8:90. http://www.jneuroinflammation.com/content/8/1/90
10. Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011 ; 13: e30
20. Miklossy J. Chronic or late Lyme neuroborreliosis: Analysis of the evidence compared to chronic or late neurosyphilis. Open J Neurology http://www.benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/78TONEUJ.pdf http://www.benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/146TONEUJ.pdf